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Cell therapy offers the potential to reset the immune system for a sustained, treatment-free remission.

Patients that qualify for a clinical trial or expanded access will be provided with a step-by-step explanation of the procedures involved and the associated risks.

What to expect when you get an infusion*

Serious and potentially life-threatening side effects can occur from CAR T-cell therapy, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), and typically resolve within the first month after treatment.

Patients receiving this treatment are always in the care of a doctor, who monitors them closely for these side effects and can treat their symptoms to help prevent their worsening.

  • Symptoms of CRS include fever, nausea, feeling tired (fatigue), and body aches, can progress in severity and may include high blood pressure and high fever, shock, and potentially organ failure.
  • Symptoms of ICANS include fatigue, uncontrolled movements (tremors), impairment in thinking, loss of speech, muscle weakness, seizures, and swelling in the brain.
    *KYV-101 is an investigational therapy.

How does CAR T-cell therapy work?

CAR T-cell therapy represents a sophisticated approach to treating autoimmune diseases. This new type of therapy involves engineering immune cells from a patient or healthy donor and infusing those cells to correct an identified defective or pathogenic mechanism. This therapeutic approach may help reset the patient’s immune system and may offer sustained therapeutic benefits, eliminating the need for chronic or suboptimal therapies.


CAR T-cell therapy may eliminate the need for chronic dosing and incremental disease control

Traditional Therapies

  • May require chronic dosing
  • May result in long-term toxicity
  • Have generally low rate of remission

Potential of CAR T-Cell Therapy

  • Reset of the immune system
  • Avoids standard of care toxicities
  • Long-term remission post-infusion1

1. Mackensen A, et al. Nat Med. 2022;28:2124-2132.